Retinoic acid signaling regulates late stages of semicircular canal morphogenesis and otolith maintenance in the zebrafish inner ear.
Kacey MackowetzkyRenée DicipuloSabrina C FoxDanielle A PhilibertHayley TodescoJainil D DoshiKoichi KawakamiKeith TierneyAndrew J WaskiewiczPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2022)
Our work has identified a previously undescribed late phase of RA activity in otic development, demonstrating that vestibular defects observed in human patients in relation to perturbed RA signaling are not solely due to its early disruption in otic development.
Keyphrases
- end stage renal disease
- rheumatoid arthritis
- endothelial cells
- newly diagnosed
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- ejection fraction
- disease activity
- peritoneal dialysis
- prognostic factors
- ankylosing spondylitis
- systemic lupus erythematosus
- patient reported outcomes
- induced pluripotent stem cells
- patient reported
- pluripotent stem cells