Toll-like receptor 2 activation primes and upregulates osteoclastogenesis via lox-1.

Kimiko OhgiHiroshi KajiyaKazuko Goto-TFujio OkamotoYasunori YoshinagaKoji OkabeRyuji Sakagami

Published in: Lipids in health and disease (2018)

This study supports that osteoclastogenesis is promoted under the coexistence of oxLDL by TLR2-induced upregulation of Lox-1 in BMCs. This indicates that periodontitis could worsen with progression of dyslipidemia.

Keyphrases

toll like receptor
inflammatory response
nuclear factor
immune response
lps induced
high glucose
poor prognosis
bone loss
signaling pathway
diabetic rats
low density lipoprotein
drug induced
oxidative stress
endothelial cells