Intracellular vorinostat accumulation and its relationship to histone deacetylase activity in soft tissue sarcoma patients.

Juergen BurhenneLu LiuChristoph E HeiligAndreas D MeidMargarete LeisenThomas SchmittBernd KasperWalter E HaefeliGerd MikusGerlinde Egerer

Published in: Cancer chemotherapy and pharmacology (2017)

HDAC inhibition closely followed intracellular vorinostat concentrations and was short-lasting, which may contribute to the limited efficacy seen with vorinostat in solid tumors so far.

Keyphrases

histone deacetylase
end stage renal disease
newly diagnosed
chronic kidney disease
reactive oxygen species
prognostic factors