Association of ERBB2 Copy Number and Gene Coalterations With Trastuzumab Efficacy and Resistance in Human Epidermal Growth Factor Receptor 2-Positive Esophagogastric and Gastric Cancer.
Kaori HinoTomohiro NishinaTakeshi KajiwaraHideaki BandoMaho NakamuraShigenori KadowakiKeiko MinashiSatoshi YukiTakashi OhtaHiroki HaraTakuro MizukamiToshikazu MoriwakiKoushiro OhtsuboMasato KomodaSeiichiro MitaniFumio NagashimaKen KatoTakanobu YamadaHiroko HasegawaKentaro YamazakiTakayuki YoshinoIchinosuke HyodoPublished in: JCO precision oncology (2022)
showed poor outcomes and may need HER2 tyrosine kinase inhibitors and trastuzumab deruxtecan.