Login / Signup

Chromatin accessibility and transcription dynamics during in vitro astrocyte differentiation of Huntington's Disease Monkey pluripotent stem cells.

Alexandra V GoodnightIsaac KremskySujittra KhampangYoon Hee JungJames M BillingsleySteven E BosingerVictor G CorcesAnthony W S Chan
Published in: Epigenetics & chromatin (2019)
The results suggest that chromatin accessibility and transcription are altered throughout in vitro HD astrocyte differentiation and provide evidence that E2F dysregulation contributes to aberrant cell-cycle re-entry and apoptosis throughout the progression from NPCs to astrocytes.
Keyphrases
  • cell cycle
  • transcription factor
  • pluripotent stem cells
  • cell proliferation
  • dna damage
  • gene expression
  • genome wide
  • oxidative stress
  • endoplasmic reticulum stress
  • cell death
  • cell cycle arrest