Propofol inhibits myocardial injury induced by microvesicles derived from hypoxia-reoxygenated endothelial cells via lncCCT4-2/CCT4 signaling.

Xiaojun ZhangChangsen WangHao XuShuyun CaiKeyu LiuSimeng LiLinming ChenSiman ShenXiaoxia GuJing TangZhengyuan XiaZhe HuXiaotang MaLiangqing Zhang

Published in: Biological research (2023)

Our study showed that (HR + P)-EMVs uptake by IR-injured cardiomyocytes upregulated lncCCT4-2 in cardiomyocytes and promoted CCT4 expression, thereby inhibiting HR-EMVs induced oxidative stress and apoptosis.

Keyphrases

endothelial cells
high glucose
oxidative stress
poor prognosis
cell death
hydrogen peroxide
endoplasmic reticulum stress
signaling pathway
cell cycle arrest