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Propofol inhibits myocardial injury induced by microvesicles derived from hypoxia-reoxygenated endothelial cells via lncCCT4-2/CCT4 signaling.

Xiaojun ZhangChangsen WangHao XuShuyun CaiKeyu LiuSimeng LiLinming ChenSiman ShenXiaoxia GuJing TangZhengyuan XiaZhe HuXiaotang MaLiangqing Zhang
Published in: Biological research (2023)
Our study showed that (HR + P)-EMVs uptake by IR-injured cardiomyocytes upregulated lncCCT4-2 in cardiomyocytes and promoted CCT4 expression, thereby inhibiting HR-EMVs induced oxidative stress and apoptosis.
Keyphrases
  • endothelial cells
  • high glucose
  • oxidative stress
  • poor prognosis
  • cell death
  • hydrogen peroxide
  • endoplasmic reticulum stress
  • signaling pathway
  • cell cycle arrest