N-acetyl-cysteine as adjuvant therapy in female infertility: a systematic review and meta-analysis.
Nagita DeviChandrasekhar BoyaManik ChhabraDipika BansalPublished in: Journal of basic and clinical physiology and pharmacology (2020)
NAC can be an effective adjuvant in PCOS related and unexplained female infertility. The effect could be more profound in women with high BMI, insulin resistance, and oxidative stress. However, the findings need further confirmation in well-designed randomized controlled trials to examine clinical outcomes such as live birth rate in more extended follow-up periods.
Keyphrases
- polycystic ovary syndrome
- insulin resistance
- oxidative stress
- randomized controlled trial
- adipose tissue
- metabolic syndrome
- early stage
- transcription factor
- body mass index
- type diabetes
- high fat diet
- skeletal muscle
- dna damage
- intellectual disability
- gestational age
- high fat diet induced
- clinical trial
- fluorescent probe
- weight gain
- systematic review
- pregnant women
- glycemic control
- double blind