Transpulmonary Expression of Exosomal microRNAs in Idiopathic and Congenital Heart Disease-Related Pulmonary Arterial Hypertension.

Wei-Ting Chang Wei-Chieh Lee Yu-Wen Lin Jhih-Yuan Shih Chon-Seng Hong Zhih-Cherng ChenChun-Yuan ChuChih-Hsin Hsu

Published in: Journal of the American Heart Association (2023)

Our study identified a pronounced expression of transpulmonary exosomal miR-21, particularly in patients with CHD-related PAH, through next-generation sequencing analysis. Further investigation is warranted to elucidate the regulatory mechanisms involving miR-21 in the pathophysiology of PAH.

Keyphrases

pulmonary arterial hypertension
congenital heart disease
poor prognosis
long non coding rna
cell proliferation
pulmonary artery
pulmonary hypertension
long noncoding rna
binding protein
copy number
gene expression
genome wide
circulating tumor cells