Fecal Microbiota Transplantation from Overweight or Obese Donors in Cachectic Patients with Advanced Gastroesophageal Cancer: A Randomized, Double-blind, Placebo-Controlled, Phase II Study.
Nicolien C de ClercqTom van den EndeAndrei ProdanRobert HemkeMark DavidsHelle Krogh PedersenHenrik Bjørn NielsenA K GroenWillem M de VosHanneke W M van LaarhovenMax NieuwdorpPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
FMT from a healthy obese donor prior to first-line chemotherapy did not affect cachexia, but may have improved response and survival in patients with metastatic gastroesophageal cancer. These results provide a rational for larger FMT trials.
Keyphrases
- placebo controlled
- phase ii study
- double blind
- papillary thyroid
- weight loss
- locally advanced
- adipose tissue
- squamous cell
- metabolic syndrome
- type diabetes
- open label
- clinical trial
- phase ii
- phase iii
- obese patients
- stem cells
- physical activity
- randomized controlled trial
- rectal cancer
- radiation therapy
- weight gain
- cell therapy
- bone marrow
- body mass index