Reductions in remnant cholesterol and VLDL cholesterol through inhibition of ANGPTL3 protein synthesis: an analysis from the TRANSLATE-TIMI 70 trial.
André ZimermanStephen D WiviottJeong-Gun ParkSabina A MurphyXinhui RanCandace R BramsonMadelyn CurtoVesper RamosAlexandra JevneJulia F KuderSubodh VermaWojtek WojakowskiSteven G TerraMarc S SabatineBrian A BergmarkNicholas A MarstonPublished in: European journal of preventive cardiology (2024)
Inhibition of ANGPTL3 protein synthesis significantly lowered remnant cholesterol and VLDL-C in patients with hypertriglyceridaemia. The magnitude of reduction was associated with the degree of ANGPTL3 inhibition. These findings support ANGPTL3 inhibition as a promising target for lowering cholesterol on triglyceride-rich lipoproteins.