The risk of acute liver injury among users of antibiotic medications: a comparison of case-only studies.

Ruth BrauerAna RuigómezOlaf KlungelRobert ReynoldsMaurille Feudjo TepieLiam SmeethIan Douglas

Published in: Pharmacoepidemiology and drug safety (2015)

An increased relative risk of acute liver injury was consistently observed using both self-controlled case series and case-crossover designs. Case-only designs can be used as a viable alternative study design to study the risk of acute liver injury, albeit with some limitations.

Keyphrases

liver injury
drug induced
liver failure
randomized controlled trial
aortic dissection
open label
hepatitis b virus
study protocol