Inflammatory bowel disease induces pathological α-synuclein aggregation in the human gut and brain.
Ana M Espinosa-OlivaRocío RuizManuel Sarmiento SotoAntonio Boza-SerranoAna I Rodriguez-PerezMaría A Roca-CeballosJuan García-RevillaMarti SantiagoSébastien SerresVasiliki EconomopoulusAna E CarvajalMaría D Vázquez-CarreteroPablo García-MirandaOxana KlementievaMaría J Oliva-MartínTomas DeierborgEloy RivasNicola R SibsonJose Luis Labandeira-GarciaAlberto MachadoMaría J PeralAntonio J HerreraJosé L VeneroRocío M de PablosPublished in: Neuropathology and applied neurobiology (2024)
These results strongly support the plausibility of Braak's hypothesis and emphasise the significance of peripheral inflammation and the gut-brain axis in initiating α-syn aggregation and transport to the substantia nigra, resulting in neurodegeneration.