From GWAS to functional variants: ARL14 cis-regulatory variants are associated with severe malaria.

Mathieu AdjemoutFrederic GallardoMagali TorresAlassane ThiamBabacar MbengueAlioune DieyeSandrine MarquetPascal Rihet

Published in: The Journal of infectious diseases (2024)

We suggest that these SNPs regulate ARL14 expression in immune cells and the presentation of antigens to T lymphocytes, thus influencing severe malaria development.

Keyphrases

copy number
plasmodium falciparum
early onset
poor prognosis
genome wide
transcription factor
dendritic cells
gene expression
case report