Nitrobenzyl-based fluorescent photocages for spatial and temporal control of signalling lipids in cells.

Pankaj GaurOleksandr A KucherakYulia G ErmakovaVolodymyr V ShvadchakDmytro A Yushchenko

Published in: Chemical communications (Cambridge, England) (2019)

Here we present a set of fluorescent cages prepared by tethering fluorescent dyes to a photolabile group. The developed molecules enable caging of signalling lipids, their delivery to specific cellular membranes, with further imaging, quantification, and controlled photorelease of active lipids in living cells.

Keyphrases

living cells
fluorescent probe
single molecule
induced apoptosis
fatty acid
quantum dots
high resolution
cell cycle arrest
cell death
oxidative stress
signaling pathway
cell proliferation