Insulin resistance rewires the metabolic gene program and glucose utilization in human white adipocytes.

Marie Sophie Isidor Wentao Dong Rogelio I Servin-UribeJulia VillarroelAli AltıntaşJ Tonatiuh Ayala-SumuanoAlfredo Varela-EchavarríaRomain BarresGregory StephanopoulosYazmín MacotelaBrice Emanuelli

Published in: International journal of obesity (2005) (2021)

Collectively, our data highlight the importance of obesity-derived insulin resistance in impacting the expression of key metabolic genes and impairing the metabolic processes of glucose utilization, and reveal a role for metabolic adaptation in adipose dysfunction in humans.

Keyphrases

insulin resistance
adipose tissue
genome wide
metabolic syndrome
type diabetes
high fat diet induced
poor prognosis
endothelial cells
weight loss
blood glucose
copy number
gene expression
polycystic ovary syndrome
electronic health record
binding protein
big data
deep learning
physical activity
transcription factor