Effects of PNPLA3 I148M on hepatic lipid and very-low-density lipoprotein metabolism in humans.
Jan BorénMartin AdielsElias BjörnsonNiina MatikainenSanni SöderlundJoel RämöMarcus HenricssonPietari RipattiSamuli RipattiAarno PalotieRosellina M MancinaMari AinolaAntti HakkarainenStefano RomeoChris J PackardMarja-Riitta TaskinenPublished in: Journal of internal medicine (2021)
Despite the higher liver fat content in PNPLA3 148M homozygotes, there was no increase in VLDL production. Equally, VLDL production was maintained at normal levels despite the putative impairment in cytosolic lipid hydrolysis in these subjects.