Heterogeneity of miRNA expression in localized prostate cancer with clinicopathological correlations.

Ahmed Hussein ZedanSøren Garm BlavnsfeldtTorben Frøstrup HansenBoye Schnack NielsenNiels MarcussenMindaugas PleckaitisPalle Jörn Sloth OstherFlemming Brandt Sørensen

Published in: PloS one (2017)

The present study documents significant upregulation of the expression of miRNA-21, miRNA-34a, miRNA-125, and miRNA-126 in PCa compared to BPH and suggests a possible prognostic value associated with the expression of miRNA-143. The results, however, document intra-tumoral heterogeneity in the expression of various miRNAs calling for caution when using these tumor tissue biomarkers in prognostic and predictive settings.

Keyphrases

poor prognosis
prostate cancer
binding protein
long non coding rna
single cell
signaling pathway
radical prostatectomy