Phosphatidylserine in the Nervous System: Cytoplasmic Regulator of the AKT and PKC Signaling Pathways and Extracellular "Eat-Me" Signal in Microglial Phagocytosis.
Junyi ZhuangYuchen ZhangHuichen ShuShibo ZhangWanwei ZhaoNatalie WardJiao WangPublished in: Molecular neurobiology (2022)
Phosphatidylserine (PtdSer) is an important anionic phospholipid found in eukaryotic cells and has been proven to serve as a beneficial factor in the treatment of neurodegenerative diseases. PtdSer resides in the inner leaflet of the plasma membrane, where it is involved in regulating the AKT and PKC signaling pathways; however, it becomes exposed to the extracellular leaflet during neurodevelopmental processes and neurodegenerative diseases, participating in microglia-mediated synaptic and neuronal phagocytosis. In this paper, we review several characteristics of PtdSer, including the synthesis and translocation of PtdSer, the functions of cytoplasmic and exposed PtdSer, and different PtdSer-detection materials used to further understand the role of PtdSer in the nervous system.
Keyphrases
- signaling pathway
- induced apoptosis
- mitral valve
- pi k akt
- aortic valve
- inflammatory response
- cell cycle arrest
- epithelial mesenchymal transition
- neuropathic pain
- cell proliferation
- endoplasmic reticulum stress
- lps induced
- heart failure
- protein kinase
- fatty acid
- real time pcr
- replacement therapy
- prefrontal cortex
- quantum dots
- sensitive detection