Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B.

Amy C JusticeKathleen A McGinnisJanet P TateKe XuWilliam C BeckerHongyu ZhaoJoel GelernterHenry R Kranzler

Published in: Alcoholism, clinical and experimental research (2017)

EHR data can be used to identify complex phenotypes such as harmful alcohol use. The validity of the phenotype may be enhanced through the use of longitudinal trajectories.

Keyphrases

electronic health record
small molecule
depressive symptoms
genome wide
big data
high throughput
cross sectional
copy number
dna methylation
machine learning
deep learning