Enhanced efficacy and limited systemic cytokine exposure with membrane-anchored interleukin-12 T-cell therapy in murine tumor models.
Ling ZhangJohn S DaviesCarylinda SernaZhiya YuNicholas P RestifoSteven A RosenbergRichard A MorganChristian S HinrichsPublished in: Journal for immunotherapy of cancer (2020)
Expression of aIL-12 by tumor-targeting therapeutic T cells demonstrated low systemic exposure and improved efficacy. This treatment strategy may have broad applications to cellular therapy with tumor-infiltrating lymphocytes, chimeric antigen receptor T cells, and TCR T cells.