Chlorpromazine induces cytotoxic autophagy in glioblastoma cells via endoplasmic reticulum stress and unfolded protein response.
Silvia MatteoniPaola MatarreseBarbara AscioneLucia Ricci-VitianiRoberto PalliniVeronica VillaniAndrea PaceMarco G PaggiClaudia AbbruzzesePublished in: Journal of experimental & clinical cancer research : CR (2021)
This discrepancy could be central in explaining the lethal effects of the drug on GBM cells and the relatively scarce cytotoxicity toward normal tissues attributed to this compound. The data presented here offer support to the multicenter phase II clinical trial we have undertaken, which consists of the addition of CPZ to first-line treatment of GBM patients carrying a hypo- or un-methylated MGMT gene, i.e. those characterized by intrinsic resistance to temozolomide.
Keyphrases
- endoplasmic reticulum stress
- induced apoptosis
- clinical trial
- phase ii
- newly diagnosed
- signaling pathway
- cell cycle arrest
- oxidative stress
- end stage renal disease
- open label
- cell death
- chronic kidney disease
- gene expression
- double blind
- ejection fraction
- peritoneal dialysis
- artificial intelligence
- copy number
- amino acid
- patient reported outcomes
- cross sectional
- deep learning