Global and Regional DNA methylation silencing of PPARγ Associated with Glioblastoma Multiforme Pathogenesis.
Esmaeel BabaeenezhadMostafa Moradi SarabiMasumeh Rajabi BazlSaeed Oraee-YazdaniSaeed KarimaPublished in: Molecular biology reports (2022)
Our study demonstrated that global DNA methylation and PPARγ epigenetic silencing is associated with the GBM risk. Our data provide a novel molecular mechanistic insight into epigenetic silencing of PPARγ in GBM patients that may be relevant as a key tumor marker for GBM pathogenesis.
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