Role of Macrophage Migration Inhibitory Factor in Granulomatosis With Polyangiitis.
Antoine G SreihRana EzzedineLin LengJuan FanJie YaoDuncan ReidMarta PiecychnaSimon CaretteDavid CuthbertsonPaul DellaripaGary S HoffmanNader A KhalidiCurry L KoeningCarol A LangfordAlfred Daniel MahrCarol A McAlearKathleen Maksimowicz-MckinnonPaul A MonachPhilip SeoUlrich SpecksE William St ClairJohn H StoneSteven R YtterbergJeffrey EdbergPeter A MerkelRichard BucalaPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2018)
Patients with GPA have an increased frequency of high MIF expression CATT alleles. Higher Mif expression increases the incidence of mortality and pulmonary granulomas in Mif lung-Tg2.1 mice, while anti-MIF treatment protects these mice against death. Blockade of MIF in high genotypic MIF expressers may therefore offer a selective pharmacologic therapy for GPA.