Metabolites of the ring-substituted stimulants MDMA, methylone and MDPV differentially affect human monoaminergic systems.
Dino LuethiKarolina E KolaczynskaMelanie WalterMasaki SuzukiKenner C RiceBruce E BloughMarius C HoenerMichael H BaumannMatthias E LiechtiPublished in: Journal of psychopharmacology (Oxford, England) (2019)
Several metabolites of MDMA, methylone and MDPV interact with human transporters and receptors at pharmacologically relevant concentrations. In particular, N-demethylated metabolites of MDMA and methylone circulate in unconjugated form and could contribute to the in vivo activity of the parent compounds in human users.