Immunohistochemical assessment of symptomatic postmenopausal endometrial polyps in tamoxifen users and nonusers: a case control study.
Raquel Papandreus DibiClaudio Galleano ZettlerCarla Maria de Martini VaninRafaela Vanin Pinto RibeiroJúlia Monteiro de OliveiraThaysa Guglieri KremerJosiane BorgesSérgio Kakuta KatoPublished in: Sao Paulo medical journal = Revista paulista de medicina (2020)
The immunohistochemical analysis on endometrial polyps demonstrated that, although tamoxifen is considered to be a risk factor for endometrial polyps, there were no significant differences in the expression of hormone receptors between users and nonusers of tamoxifen. There were no between-group differences in Ki-67 and Bcl-2 expression, and all patients displayed inhibition of apoptosis by Bcl-2, thus supporting the theory that polyps develop due to inhibition of apoptosis, and not through cell proliferation.
Keyphrases
- chronic rhinosinusitis
- poor prognosis
- cell proliferation
- breast cancer cells
- end stage renal disease
- estrogen receptor
- oxidative stress
- endometrial cancer
- endoplasmic reticulum stress
- positive breast cancer
- cell cycle arrest
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- binding protein
- squamous cell carcinoma
- patient reported outcomes
- lymph node
- locally advanced