Interleukin-38 promotes tumor growth through regulation of CD8+ tumor-infiltrating lymphocytes in lung cancer tumor microenvironment.

Fumihiko KinoshitaTetsuzo TagawaTakaki AkamineKazuki TakadaYuichi YamadaYuka OkuKeisuke KosaiYuki OnoKensuke TanakaSho WakasuTaro ObaAtsushi OsoegawaMototsugu ShimokawaYoshinao OdaTomoaki HoshinoMasaki Mori

Published in: Cancer immunology, immunotherapy : CII (2020)

We demonstrated that high IL-38 expression in tumor cells was significantly associated with reduction of CD8+ TILs and tumor progression. These results suggest that IL-38 could be a therapeutic target for lung cancer.

Keyphrases

poor prognosis
nk cells
long non coding rna
peripheral blood
binding protein