Reduced leukocyte telomere lengths and sirtuin 1 gene expression in long-term survivors of type 1 diabetes: A Dialong substudy.
Trine Baur OpstadTore Julsrud BergKristine Bech HolteHarald ArnesenSvein SolheimIngebjørg SeljeflotPublished in: Journal of diabetes investigation (2020)
Long-term type 1 diabetes presented with reduced telomeres and sirtuin 1 expression, with additional reduction in diabetes patients with previous coronary artery disease, showing their importance for cardiovascular disease development with potential as novel biomarkers in diabetes and coronary artery disease.
Keyphrases
- type diabetes
- cardiovascular disease
- coronary artery disease
- glycemic control
- gene expression
- cardiovascular events
- percutaneous coronary intervention
- poor prognosis
- coronary artery bypass grafting
- young adults
- cardiovascular risk factors
- heart failure
- binding protein
- acute coronary syndrome
- climate change
- weight loss
- aortic stenosis
- atrial fibrillation
- skeletal muscle
- aortic valve