Transgenerational Inheritance of Betaine-Induced Epigenetic Alterations in Estrogen-Responsive IGF-2/IGFBP2 Genes in Rat Hippocampus.
Yang YangWenduo JiangShu YangFulei QiRuqian ZhaoPublished in: Molecular nutrition & food research (2020)
These results indicate that betaine exerts a transgenerational effect on hippocampal expression of estrogen-responsive genes in rat offspring, which is associated with corresponding alterations in DNA methylation on ICR of IGF-2 gene and the promoter of affected genes.
Keyphrases
- dna methylation
- genome wide
- genome wide identification
- gene expression
- copy number
- binding protein
- transcription factor
- oxidative stress
- genome wide analysis
- cancer therapy
- poor prognosis
- estrogen receptor
- mitochondrial dna
- pi k akt
- type diabetes
- high fat diet
- diabetic rats
- drug delivery
- metabolic syndrome
- long non coding rna
- skeletal muscle
- drug induced