Mapping Functional Connectivity Signatures of Pharmacoresistant Focal Cortical Dysplasia-Related Epilepsy.

Hua XieVenkata Sita Priyanka IllapaniL Gilbert VezinaTaha GholipourChima OluigboWilliam D GaillardNathan T Cohen

Published in: Annals of neurology (2024)

This study demonstrates diminished functional connectivity patterns in FCD-PRE, which may represent a neuromarker for the disease, independent of FCD location, involving the dorsal attention, default mode, and control functional networks. Higher connectivity to the limbic network is associated with a seizure-free outcome. Future multicenter, prospective studies are needed to allow for much earlier detection of signatures of treatment-resistant epilepsy. ANN NEUROL 2024.

Keyphrases

functional connectivity
resting state
temporal lobe epilepsy
genome wide
spinal cord
working memory
high resolution
neuropathic pain
loop mediated isothermal amplification
cross sectional
multiple sclerosis
gene expression
label free
high density
mass spectrometry
sensitive detection