Effects of β-Adrenergic Antagonists on Chemoradiation Therapy for Locally Advanced Non-Small Cell Lung Cancer.
Kunal R ChaudharySherry X YanSamuel Peter HeilbronerJoshua R SonettMark B StooplerCatherine ShuBalazs HalmosTony J C WangTom K HeiSimon K ChengPublished in: Journal of clinical medicine (2019)
β-AR blockade enhanced radiation and cisplatin sensitivity of human lung cancer cells in vitro. Use of beta-blockers is associated with decreased distant metastases and potentially improved OS and DMFS. Additional studies are warranted to evaluate the role of beta-blockers as a chemoradiation sensitizer in locally advanced NSCLC.
Keyphrases
- locally advanced
- rectal cancer
- neoadjuvant chemotherapy
- angiotensin converting enzyme
- squamous cell carcinoma
- radiation therapy
- phase ii study
- endothelial cells
- small cell lung cancer
- induced pluripotent stem cells
- angiotensin ii
- advanced non small cell lung cancer
- pluripotent stem cells
- case control
- radiation induced
- stem cells
- epidermal growth factor receptor
- mesenchymal stem cells