Predicting Therapeutic Antibody Delivery into Human Head and Neck Cancers.
Guolan LuShayan FakurnejadBrock A MartinNynke S van den BergStan van KeulenNaoki NishioAshley J ZhuStefania U ChiritaQuan ZhouRebecca W GaoChristina S KongNancy FischbeinMrudula PentaAlexander D ColevasEben L RosenthalPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
This study provides a clinically translatable platform to measure antibody delivery into solid tumors and yields valuable insight into clinically relevant antibody tumor penetration, with implications in the selection of patients amenable to antibody therapy and the design of more effective dosing strategies.