Gene expression of adipokines and adipokine receptors in the tumor microenvironment: associations of lower expression with more aggressive breast tumor features.
Adana A M LlanosSong YaoAmartya SinghJohn B AremuHossein KhiabanianYong LinCoral OmeneAngela R OmilianThaer KhouryChi-Chen HongShridar GanesanDavid J ForanMichael J HigginsChristine B AmbrosoneElisa V BanderaKitaw DemissiePublished in: Breast cancer research and treatment (2020)
These findings suggest that lower expression of ADIPOQ, ADIPOR2, LEP, and LEPR in the breast TME might be indicators of more aggressive breast cancer phenotypes. Validation of these findings are warranted to elucidate the role of the adipokines and adipokine receptors in long-term breast cancer prognosis.