Gene Expression Changes in Glutamate and GABA-A Receptors, Neuropeptides, Ion Channels, and Cholesterol Synthesis in the Periaqueductal Gray Following Binge-Like Alcohol Drinking by Adolescent Alcohol-Preferring (P) Rats.

Jeanette N McClintickWilliam J McBrideRichard L BellZheng-Ming DingYunlong LiuXiaoling XueiHoward J Edenberg

Published in: Alcoholism, clinical and experimental research (2016)

The results demonstrate that binge alcohol drinking during adolescence produces developmental changes in the expression of key genes within the PAG; many of these changes point to increased susceptibility to pain, fear, and anxiety, which could contribute to excessive drinking to relieve these negative effects.

Keyphrases

alcohol consumption
gene expression
chronic pain
poor prognosis
dna methylation
young adults
depressive symptoms
mental health
genome wide
neuropathic pain
weight loss
sleep quality
low density lipoprotein
postoperative pain
bioinformatics analysis