Login / Signup

The First Total Synthesis of the Lipid Mediator PD2n-3 DPA.

Jørn Eivind TungenKaroline Gangestad PrimdahlTrond Vidar Hansen
Published in: Journal of natural products (2020)
The resolution of inflammation is governed by the active biosynthesis of specialized pro-resolving mediators using ω-6 and ω-3 polyunsaturated fatty acids as substrates. These mediators act as resolution agonists and display several interesting bioactivities. PD2n-3 DPA is an oxygenated polyunsaturated fatty acid biosynthesized from n-3 docosapentaenoic acid belonging to the specialized pro-resolving lipid mediator family named protectins. The protectins exhibit anti-inflammatory properties and pro-resolving bioactivities. These endogenously produced compounds are of interest as leads in resolution pharmacology and drug development. Herein, together with its NMR, MS, and UV data, a stereoselective total synthesis of PD2n-3 DPA is presented.
Keyphrases
  • fatty acid
  • anti inflammatory
  • single molecule
  • palliative care
  • oxidative stress
  • mass spectrometry
  • magnetic resonance
  • electronic health record
  • ms ms
  • high resolution
  • big data
  • deep learning
  • silver nanoparticles