Clinical significance of long non-coding RNA ZEB2-AS1 and EMT-related markers in ductal and lobular breast cancer.

Mahboobeh Zarei Kianoosh Malekzadeh Mahmoud Omidi Mousavi Pegah

Published in: Cancer reports (Hoboken, N.J.) (2023)

Collectively, our findings suggest that ZEB2-AS1 expression is significantly upregulated in tumor tissues, especially in advanced stages and ZEB2-AS1 is associated with the aggressiveness of tumors by functioning as putative oncogenic lncRNA. In addition, a combination of ZEB2-AS1 and these EMT markers in breast cancer potentiates these genes as biomarkers for tumor progression.

Keyphrases

long non coding rna
poor prognosis
epithelial mesenchymal transition
gene expression
dna methylation