Characterisation of DEHAL1 expression in thyroid pathologies.

Kerstin KrauseStefan KargerOliver GimmSien-Yi SheuHenning DralleAndrea TannapfelKurt Werner SchmidCorinne DupuyDagmar Fuhrer

Published in: European journal of endocrinology (2007)

Upregulation of DEHAL1 protein expression and sublocalisation of DEHAL1 at the apical cell pole in TTNs and GD thyroids is consistent with increased thyroid hormone turnover during thyrotoxicosis. Diffuse cytoplasmatic localisation or downregulation of DEHAL1 expression in thyroid cancers suggests alteration or loss of DEHAL1 function during thyroid cell dedifferentiation.

Keyphrases

poor prognosis
single cell
cell therapy
cell proliferation
signaling pathway
stem cells
bone marrow