Uncovering Unrecognized Heart Failure With Preserved Ejection Fraction Among Individuals With Obesity and Dyspnea.
Leah B KosyakovskyElizabeth E LiuJessica K WangLisa MyersJuhi K ParekhHanna KnaussGregory D LewisRajeev MalhotraMatthew NayorJeremy M RobbinsRobert E GersztenNaomi M HamburgJenna N McNeillEmily S LauJennifer E HoPublished in: Circulation. Heart failure (2024)
Among adults with obesity and dyspnea without known cardiovascular disease, at least a third had clinically unrecognized HFpEF uncovered on invasive cardiopulmonary exercise testing. Clinical, biomarker, resting echocardiography, and diagnostic scores were similar among those with and without HFpEF. These results suggest clinical underdiagnosis of HFpEF among individuals with obesity and dyspnea and highlight limitations of noninvasive testing in the identification of HFpEF.
Keyphrases
- insulin resistance
- metabolic syndrome
- weight loss
- type diabetes
- cardiovascular disease
- high fat diet induced
- weight gain
- computed tomography
- physical activity
- left ventricular
- advanced cancer
- skeletal muscle
- adipose tissue
- coronary artery disease
- heart rate variability
- palliative care
- heart failure
- blood pressure
- resistance training