Cellular Response of Ventricular-Subventricular Neural Progenitor/Stem Cells to Neonatal Hypoxic-Ischemic Brain Injury and Their Enhanced Neurogenesis.
Jeong Eun ShinHaejin LeeKwangsoo JungMiri KimKyujin HwangJeong Ho HanJoo Hee LimIl Sun KimKwang-Il LimKook In ParkPublished in: Yonsei medical journal (2020)
HI promotes the establishment of a substantial number of new neurons in non-neurogenic regions, suggesting intrinsic repair mechanisms of the brain, by controlling the behavior of endogenous NSPCs. The activation of NeuroD1 expression may improve the therapeutic potential of endogenous NSPCs by increasing their neuronal differentiation in HI.
Keyphrases
- brain injury
- cerebral ischemia
- subarachnoid hemorrhage
- stem cells
- poor prognosis
- spinal cord injury
- heart failure
- spinal cord
- left ventricular
- blood brain barrier
- binding protein
- cell therapy
- long non coding rna
- resting state
- white matter
- mesenchymal stem cells
- catheter ablation
- atrial fibrillation
- multiple sclerosis
- bone marrow