Estrogen regulates the expression of SARS-CoV-2 receptor ACE2 in differentiated airway epithelial cells.

Kimberly E StelzigFabrizio Canepa-EscaroMarta SchiliroSergejs BerdnikovsY S PrakashSergio E Chiarella

Published in: American journal of physiology. Lung cellular and molecular physiology (2020)

There is marked sexual dimorphism in the current coronavirus disease 2019 (COVID-19) pandemic. Here we report that estrogen can regulate the expression of angiotensin-converting enzyme 2 (ACE2), a key component for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry, in differentiated airway epithelial cells. Further studies are required to elucidate the mechanisms by which sex steroids regulate SARS-CoV-2 infectivity.

Keyphrases

sars cov
respiratory syndrome coronavirus
angiotensin converting enzyme
coronavirus disease
angiotensin ii
poor prognosis
binding protein
estrogen receptor
mental health
single cell
cell therapy
stem cells
bone marrow
mesenchymal stem cells