MEG3: an Oncogenic Long Non-coding RNA in Different Cancers.
Arwa Al-RugeebahMohammed AlanaziNarasimha Reddy ParinePublished in: Pathology oncology research : POR (2019)
Long noncoding RNAs (lncRNAs) have recently considered as central regulators in diverse biological processes and emerged as vital players controlling tumorigenesis. Several lncRNAs can be classified into oncogenes and tumor suppressor genes depending on their function in cancer. A maternally expressed gene 3 (MEG3) gene transcripts a 1.6 kb lncRNA whose act as an antitumor component in different cancer cells, such as breast, liver, glioma, colorectal, cervical, gastric, lung, ovarian and osteosarcoma cancer cells. The present review highlights biological function of MEG3 to repress tumor through regulating the major tumor suppressor genes p53 and Rb, inhibiting angiogenesis-related factor, or controlling miRNAs. On the other hand, previous studies have also suggested that MEG3 mediates epithelial-mesenchymal transition (EMT). However, deregulation of MEG3 is associated with the development and progression of cancer, suggesting that MEG3 may function as a potential biomarker and therapeutic target for human cancers.
Keyphrases
- long non coding rna
- genome wide identification
- epithelial mesenchymal transition
- genome wide
- resting state
- transcription factor
- endothelial cells
- genome wide analysis
- papillary thyroid
- poor prognosis
- functional connectivity
- signaling pathway
- squamous cell
- copy number
- dna methylation
- gene expression
- vascular endothelial growth factor
- young adults
- long noncoding rna
- induced pluripotent stem cells