Phase III Randomized, Placebo-Controlled Clinical Trial of Donepezil for Treatment of Cognitive Impairment in Breast Cancer Survivors After Adjuvant Chemotherapy (WF-97116).

Stephen R Rapp Emily V Dressler W Mark Brown James L WadeNguyet Le-LindqwisterDavid KingKendrith M RowlandKathryn E Weaver Heidi D KlepinEdward G ShawGlenn J Lesser

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)

BCS 1-5 years after completing chemotherapy with documented memory problems, randomly assigned to 24 weeks of 5-10 mg of donepezil once daily, did not perform differently at the end of treatment on tests of memory, other cognitive functions, or subjective functioning than those randomly assigned to placebo.

Keyphrases

phase iii
double blind
placebo controlled
clinical trial
open label
phase ii
cognitive impairment
study protocol
randomized controlled trial
mental health
working memory
physical activity
squamous cell carcinoma
locally advanced
rectal cancer
smoking cessation
radiation therapy