Nicastrin haploinsufficiency alters expression of type I interferon-stimulated genes: the relationship to familial hidradenitis suppurativa.
L CaoDavid J MoralesElisha D O RobersonPublished in: Clinical and experimental dermatology (2019)
Our data suggest a role for increased keratinocyte inflammatory responsiveness in familial HS. Confirming this phenotype and characterizing additional effects in different cell types will require study beyond cell lines, such as in primary cells and tissues.
Keyphrases
- hidradenitis suppurativa
- induced apoptosis
- early onset
- poor prognosis
- single cell
- gene expression
- oxidative stress
- cell cycle arrest
- cell therapy
- dendritic cells
- signaling pathway
- immune response
- endoplasmic reticulum stress
- binding protein
- bone marrow
- long non coding rna
- dna methylation
- machine learning
- mesenchymal stem cells
- transcription factor
- genome wide analysis