Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects.

Wai Long TamLuís Freitas MendesXike ChenRaphaëlle LesageInge Van HovenElke LeysenGreet KerckhofsKathleen BosmansYoke Chin ChaiAkihiro YamashitaNoriyuki TsumakiLiesbet GerisScott J RobertsFrank P Luyten

Published in: Stem cell research & therapy (2021)

These results highlight the promise of induced pluripotent stem cell technology for the creation of functional cartilage tissue intermediates that can be explored for novel bone healing strategies.

Keyphrases

stem cells
bone mineral density
endothelial cells
induced pluripotent stem cells
high glucose
soft tissue
bone loss
bone regeneration
diabetic rats
big data
postmenopausal women
pluripotent stem cells
extracellular matrix
machine learning
body composition