Factors Associated With Premature Termination of Hyperacute Stroke Trials: A Review.
Yasmin Ninette AzizHeidi J SucharewMathew J ReevesJoseph P BroderickPublished in: Journal of the American Heart Association (2024)
Nearly half of acute stroke trials were terminated prematurely. Broadening inclusion criteria and simplifying trial design may decrease the likelihood of unplanned termination, whereas planned futility analyses may appropriately terminate trials early, saving money and resources.