Growing Heart Valve Implants for Children.
Haley KonsekCurry SherardCora BisbeeLillian KangJoseph W TurekTaufiek K RajabPublished in: Journal of cardiovascular development and disease (2023)
The current standard of care for pediatric patients with unrepairable congenital valvular disease is a heart valve implant. However, current heart valve implants are unable to accommodate the somatic growth of the recipient, preventing long-term clinical success in these patients. Therefore, there is an urgent need for a growing heart valve implant for children. This article reviews recent studies investigating tissue-engineered heart valves and partial heart transplantation as potential growing heart valve implants in large animal and clinical translational research. In vitro and in situ designs of tissue engineered heart valves are discussed, as well as the barriers to clinical translation.
Keyphrases
- aortic valve
- heart failure
- mitral valve
- aortic stenosis
- atrial fibrillation
- ejection fraction
- aortic valve replacement
- transcatheter aortic valve implantation
- soft tissue
- healthcare
- end stage renal disease
- newly diagnosed
- randomized controlled trial
- gene expression
- dna methylation
- chronic kidney disease
- copy number
- systematic review
- quality improvement
- genome wide
- health insurance
- meta analyses