TLR2-mediated innate immune priming boosts lung anti-viral immunity.

Jason L N GirkinSu-Ling LooCamille EsneauSteven MaltbyFrancesca MercuriBrendon ChuaAndrew T ReidPunnam Chander VeeratiChris L GraingePeter A B WarkDarryl KnightDavid C JacksonChristophe DemaisonNathan W Bartlett

Published in: The European respiratory journal (2021)

Airway epithelial cell TLR2 activation induces prolonged innate immune priming, defined by early NF-κB activation, IFN-λ expression and lymphocyte recruitment. This response enhanced anti-viral innate immunity and reduced virus-induced airway inflammation.

Keyphrases

innate immune
immune response
toll like receptor
inflammatory response
sars cov
nuclear factor
poor prognosis
lps induced
high glucose
signaling pathway
dendritic cells
oxidative stress
binding protein
drug induced
endothelial cells
long non coding rna