Melatonin rescued interleukin 1β-impaired chondrogenesis of human mesenchymal stem cells.
Bo GaoWenjie GaoZizhao WuTaifeng ZhouXianjian QiuXudong WangChengjie LianYan PengAnjing LiangJincheng QiuYuanxin ZhuCaixia XuYibing LiPeiqiang SuDongsheng HuangPublished in: Stem cell research & therapy (2018)
The current evaluation showed that MLT can save IL-1β-impaired chondrogenesis of human BMSCs by restoring the pellet size and matrix accumulation, and maintaining the metabolic balance, reducing cell apoptosis. Our study also showed that MLT can attenuate the IL-1β-induced activation of the NF-κB signaling pathway, which is the most important pathway downstream of IL-1β, and plays a crucial role in inflammation, apoptosis, and metabolism. Thus, MLT has prospects for treating OA due to its multifaceted functions, such as mitigating inflammation, maintaining metabolic balance, and mitigating apoptosis.
Keyphrases
- oxidative stress
- signaling pathway
- endothelial cells
- mesenchymal stem cells
- diabetic rats
- pi k akt
- cell cycle arrest
- endoplasmic reticulum stress
- high glucose
- induced pluripotent stem cells
- cell death
- pluripotent stem cells
- bone marrow
- stem cells
- epithelial mesenchymal transition
- knee osteoarthritis
- nuclear factor
- lps induced
- toll like receptor