CFTR gene mutation spectrum among 735 Iranian patients with cystic fibrosis: A comprehensive systematic review.
Reza AlibakhshiAboozar MohammadiSahand KhamooshianMohsen KazeminiaKeivan MoradiPublished in: Pediatric pulmonology (2021)
In this study, the spectrum and frequency of cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations previously reported among Iranian cystic fibrosis (CF) patients have been reviewed and discussed. Using the keywords of Cystic Fibrosis, CF, CFTR, and Iran, along with their Persian equivalents, a comprehensive search was performed on the online databases. After applying the inclusion and exclusion criteria, 16 articles with an overall sample of 735 Iranian patients with CF, were included in this systematic review. A total of 101 different CFTR gene variants had been reported. The mutation of p.Phe508del (c.1521_1523delCTT) (21.22%) was the most frequent one among Iranian patients with CF. In conclusion, due to the fact that in many provinces of Iran no specific study has been done so far, it seems that the CFTR gene mutation spectrum in patients with CF from Iran is much wider.
Keyphrases
- cystic fibrosis
- systematic review
- pseudomonas aeruginosa
- lung function
- meta analyses
- ejection fraction
- copy number
- end stage renal disease
- newly diagnosed
- social media
- transcription factor
- randomized controlled trial
- gene expression
- prognostic factors
- dna methylation
- chronic obstructive pulmonary disease
- air pollution
- health information