Maternal exposure to Di-n-butyl phthalate (DBP) inhibit orexin receptor 1 (OX1R) expression to prevent Sertoli cells proliferation through the AKT signaling pathway.

Zhiwen Xie Juntao Jiang Tiewen Li Xinyu Xu Lei Wu Yongqing Zhang Min Chen Yang Sun

Published in: Toxicology research (2024)

DBP can induce Sertoli cell apoptosis through its toxicological effect by suppressing OX1R and p-AKT expression, which provide a novel insight on the role of neurotransmitter receptors.

Keyphrases

signaling pathway
induced apoptosis
poor prognosis
pi k akt
cell proliferation
cell cycle arrest
epithelial mesenchymal transition
binding protein
long non coding rna
endoplasmic reticulum stress
cystic fibrosis
staphylococcus aureus
body mass index
birth weight
physical activity
escherichia coli