STEMIN and YAP5SA synthetic modified mRNAs regenerate and repair infarcted mouse hearts.

Siyu XiaoRui Liang Emilio Y Lucero Bradley K McConnellZhishi ChenJiang ChangStephen Navran Robert J Schwartz Dinakar Iyer

Published in: The journal of cardiovascular aging (2022)

STEMIN and YAP5SA mmRNA improved cardiac function and myocardial fibrosis in left ventricles of infarcted adult mice. The combinatorial use of mmRNA encoding STEMIN and YAP5SA has the potential to become a powerful clinical strategy to treat human heart disease.

Keyphrases

endothelial cells
left ventricular
pulmonary hypertension
induced pluripotent stem cells
heart failure
pluripotent stem cells
human health
young adults
climate change
childhood cancer